This study sought to investigate the effects of the enhanced recovery after surgery (ERAS) program on postoperative recovery and nutritional status in patients with colorectal cancer undergoing laparoscopic surgery. A total of 37 patients were included: 19 in the experimental group and 18 in the control group. The experimental group was supplemented with carbohydrate drinks before and after surgery, and the control group was maintained with fasting and water intake in the traditional method. Both care management and nutrition education were implemented for both groups. Patients were evaluated for physical condition, clinical indicators, blood tests, pain, length of stay, nutritional status, and nutrient intake. Use of the ERAS program for the experimental group resulted in shorter length of stay (p = 0.006), less pain (p < 0.001), and a lower rate of malnutrition (p = 0.014) compared with controls. In conclusion, carbohydrate drinks provide great advantages by reducing discomfort, such as pain or thirst, during fasting in patients after colon cancer surgery, helping patients to eat comfortably and actively, minimizing insulin resistance, maintaining nitrogen balance, and reducing infection and anastomosis leakage. For use of ERAS as a standardized program, repeated and expanded research is needed, and a Korean-style ERAS should be prepared by using this approach for various diseases.

Citations

Citations to this article as recorded by  

• Complications and length of stay after enhanced recovery after surgery compared to conventional care in colorectal cancer patients in Northern Italy
  Massimiliano Fabozzi, Federica Mereu, Francesco Marinelli, Isabella Bisceglia, Maurizio Zizzo, Andrea Morini, Fortunato Morabito, Magda Zanelli, Antonino Neri, Carmine Pinto, Lucia Mangone
  Frontiers in Surgery.2025;[Epub]     CrossRef
• Differentially expressed miR-4310 functions as a tumor suppressor in colorectal cancer
  Ziwei Jiang, Peiling Yi, Jinping You, Erwei Cai
  Technology and Health Care.2024; 32(2): 1043.     CrossRef
• Clinical study of enhanced recovery after surgery in laparoscopic appendectomy for acute appendicitis
  Zhu-Lin Li, Hua-Chong Ma, Yong Yang, Jian-Jun Chen, Zhen-Jun Wang
  World Journal of Gastrointestinal Surgery.2024; 16(3): 816.     CrossRef
• Thoracic day surgery versus thoracic inpatient surgery for treatment of patients with lung cancer: a systematic review and meta-analysis
  Cheng Shen, Guowei Che
  Journal of Cardiothoracic Surgery.2023;[Epub]     CrossRef
• Enhanced Recovery After Surgery Is Still Powerful for Colorectal Cancer Patients in COVID-19 Era
  Li Tan, Dong Peng, Yong Cheng
  Journal of Laparoendoscopic & Advanced Surgical Techniques.2023; 33(3): 257.     CrossRef

Chronic inflammation is a major etiology of cancer. Accumulating epidemiological and experimental evidences suggest that intake of high protein diet (HPD) is associated with colitis-associated colon cancer, however, most of the studies were confined in colon. Systemic influence of HPD on inflammation indices in different tissues of an organism has never been studied. We therefore investigated the effect of HPD on mouse skin and colonic inflammation using the well characterized inflammation induction protocol in both tissues (12-O-tetradecanoylphorbol-13-acetate [TPA] for skin and dextran sodium sulfate [DSS] for colon). ICR mice were grouped to normal diet (ND, 20% casein) or HPD (50% casein) groups. In each diet group, mice were treated with either vehicle (acetone or H₂O), TPA, TPA and DSS, or DSS. Experimental diet was fed for total 4 weeks. After 1 week of diet feeding, 6.5 nmol of TPA was topically applied twice a week for 2 weeks on the shaved mouse dorsal skin. Drinking water containing 2% DSS was administered for 7 days at the final week of experiment. The results showed that TPA-induced skin hyperplasia, epidermal cell proliferation, and cyclooxygenase-2 (COX-2) expression were reduced in HPD group compared to ND group. In contrast, HPD increased DSS-induced colon mucosal hyperplasia, colonocyte proliferation, COX-2 expression, and plasma nitric oxide compared to ND group. This suggests that HPD exerts differential effect on different tissue inflammation which implies efficacy of protein intervention to human also should be monitored more thoroughly.

Citations

Citations to this article as recorded by  

• Notch dimerization provides robustness against environmental insults and is required for vascular integrity
  Kristina Preusse, Kim Cochran, Quanhui Dai, Raphael Kopan, Kenji Tanigaki
  PLOS ONE.2025; 20(1): e0311353.     CrossRef
• Review of exosomes and their potential for veterinary medicine
  Mohammad Heidarpour, Mark Krockenberger, Peter Bennett
  Research in Veterinary Science.2024; 168: 105141.     CrossRef
• Macronutrient-differential dietary pattern impacts on body weight, hepatic inflammation, and metabolism
  Yuan-yuan Li, Supradeep S. Madduri, Erika T. Rezeli, Charlene Santos, Herman Freeman III, Jing Peng, Susan L. McRitchie, Wimal Pathmasiri, Stephen D. Hursting, Susan J. Sumner, Delisha A. Stewart
  Frontiers in Nutrition.2024;[Epub]     CrossRef
• Effect of isolated protein diet on remodeling of the bronchial-alveolar-vascular microaxis of the lungs
  Aycholpon Israilova, Elmira Mamytova, Yusuf Shidakov, Ayna Mamytova
  Heart, Vessels and Transplantation.2023; 7(Issue 4): 296.     CrossRef
• Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver
  Ante Benić, Sanja Mikašinović, Felix M. Wensveen, Bojan Polić
  Metabolites.2023; 13(2): 153.     CrossRef
• The Role of Exosomes in Inflammatory Diseases and Tumor-Related Inflammation
  Yuan Tian, Cheng Cheng, Yuchong Wei, Fang Yang, Guiying Li
  Cells.2022; 11(6): 1005.     CrossRef
• The Effect of Atopic Dermatitis and Diet on the Skin Transcriptome in Staffordshire Bull Terriers
  Johanna Anturaniemi, Sara Zaldívar-López, Huub F. J. Savelkoul, Kari Elo, Anna Hielm-Björkman
  Frontiers in Veterinary Science.2020;[Epub]     CrossRef