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"Mehran Rahimlou"

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"Mehran Rahimlou"

Original Articles
[English]
The Effect of Flaxseed Enriched Yogurt on the Glycemic Status and Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus: Randomized, Open-labeled, Controlled Study
Nazila Hasaniani, Mehran Rahimlou, Amirhossein Ramezani Ahmadi, Alireza Mehdizadeh Khalifani, Mohammad Alizadeh
Clin Nutr Res 2019;8(4):284-295.   Published online October 2, 2019
DOI: https://doi.org/10.7762/cnr.2019.8.4.284

Flaxseed is one of the rich sources of α-linolenic acid and lignan. Flaxseed and its components have antioxidant, hypolipidemic and hypoglycemic effects. The study aimed to investigate the effect of flaxseed enriched yogurt on glycemic control, lipid profiles and blood pressure in patients with type 2 diabetes. A randomized, open-labeled, controlled clinical trial was conducted on 57 patients with type 2 diabetes. Participants were assigned to receive 200 g 2.5% fat yogurt containing 30-g flaxseed or plain yogurt daily for 8 weeks. Anthropometrics and biochemical parameters were evaluated at the beginning and end of the study. After 8 weeks of supplementation, Hemoglobin A1c was significantly decreased in the intervention group compared to control (p = 0.007). Also, at the end of the study, significant differences were seen between the flaxseed enriched yogurt and control groups in triglycerides and total cholesterol concentrations (p = 0.04 and p = 0.01), systolic blood pressure and diastolic blood pressure (p = 0.02 and p = 0.002, respectively). However, we did not find any difference between 2 groups in low-density lipoprotein, high-density lipoprotein, body weight and waist circumference (p > 0.05). Our results showed that the addition of flaxseed to yogurt can be effective in the management of type 2 diabetes.

Trial Registration

ClinicalTrials.gov Identifier: NCT02436369

Citations

Citations to this article as recorded by  
  • Effect of flaxseed’s supplement on AMPKα2′s expression in non-diabetic and diabetic patients having follicular thyroid carcinoma on mitochondrial’s ATP synthase for TPC-1 cell line
    Amena Alsakran, Afaf Aldahish, Amani Alotaibi, Dalal Alshaya, Elham Alzahrani, Mohammad Alshugeer, Manal Alduwish, Dalia Domiaty, Fatimah Albani, Wedad Al-Qahtani
    Electronic Journal of Biotechnology.2025; 76: 57.     CrossRef
  • Flaxseed in Diabetes Management: Nutritional and Therapeutic Insights
    Preedhi Kapoor, Zubair Ahmad Parrey, Bilal Ahmad Mir, Ab Waheed Wani, Ritu Kumari, Gurseen Rakhra, Ridhi Joshi, Gurmeen Rakhra, Wajid Aslam Khan, Kasim Sakran Abass, Bodour S. Rajab, Arshad Farid, Saad Alghamdi
    Current Nutrition Reports.2025;[Epub]     CrossRef
  • Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial
    Sabina López-Toledo, María Pineda De la Cruz, Itzae Gutiérrez-Hurtado, Ana Gijón-Soriano, Enrique Martínez-Martínez, Carlos Valencia-Santiago, José Orellana-Centeno, Sergio Ramírez-García, Royer Pacheco-Cruz
    Nutrients.2025; 17(4): 709.     CrossRef
  • Papaya Peel Nata as a Novel Dietary Fiber Source for Glycemic Control and Gut Microbiome Restoration in Streptozotocin-Induced Diabetic Rats
    Marhaen Hardjo, Ika Yustisia, Nur Fitriana, Syahrijuita Kadir, Ilhamuddin Azis
    Natural Resources for Human Health.2025; 5(3): 462.     CrossRef
  • The effect of flaxseed supplementation on anthropometric indices, blood pressure, and lipid profile in diabetic patients: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials
    Vali Musazadeh, Shokufeh Nezamoleslami, Amir Hossein Faghfouri, Farzad Shidfar, Naheed Aryaeian
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2025; 19(5): 103241.     CrossRef
  • A review of flaxseed lignan and the extraction and refinement of secoisolariciresinol diglucoside
    Yingxue Hu, Timothy J. Tse, Youn Young Shim, Sarah K. Purdy, Young Jun Kim, Venkatesh Meda, Martin J. T. Reaney
    Critical Reviews in Food Science and Nutrition.2024; 64(15): 5057.     CrossRef
  • The Effects of Daily Consumption of Functionalized Yogurts with Sacha Inchi Oil and Interspecific Hybrid Palm Oil on the Lipid Profile and ApoB/ApoA1 Ratio of Healthy Adult Subjects
    Ruby-Alejandra Villamil, Laura-Natalia Romero, Juan-Pablo Ruiz, Diana-Cristina Patiño, Luis-Felipe Gutiérrez, Lilia-Yadira Cortés
    Foods.2024; 13(23): 3973.     CrossRef
  • Application of flaxseed as an effective approach for improving lipid profile parameters: An updated systematic review and meta-analysis of randomized controlled trials
    Amir Hossein Moridpour, Masomeh Goodarzi, Zeynab Kavyani, Negarsadat Nademi, Maziar Daneshvar, Vali Musazadeh, Amir Hossein Faghfouri
    PharmaNutrition.2024; 27: 100366.     CrossRef
  • Technological Strategies to Enhance Yogurt’s Fatty Acid Profile and Its Health-Related Effects
    Ruby-Alejandra Villamil, Lilia-Yadira Cortés, Luis-Felipe Gutiérrez
    Food Reviews International.2024; 40(2): 771.     CrossRef
  • The effects of flaxseed (Linum usitatissimum) supplementation on anthropometric indices: An updated systematic review and meta-analysis of randomized clinical trials
    Vali Musazadeh, MohammadReza Abolghasemian, Zeynab Kavyani, Amir Hossein Moridpour, Ahmad Nazari, Amir Hossein Faghfouri
    Complementary Therapies in Medicine.2024; 84: 103066.     CrossRef
  • Tracing the pathways and mechanisms involved in medicinal uses of flaxseed with computational methods and bioinformatics tools
    Sravani Joshi, Ruby Srivastava
    Frontiers in Chemistry.2024;[Epub]     CrossRef
  • Flaxseed supplementation significantly reduces hemoglobin A1c in patients with type 2 diabetes mellitus: A systematic review and meta-analysis
    Huihui Xi, Wei Zhou, Muhammad Sohaib, Yirou Niu, Ruiting Zhu, Yingze Guo, Saikun Wang, Jing Mao, Xingyu Wang, Lirong Guo
    Nutrition Research.2023; 110: 23.     CrossRef
  • Functional yogurt, enriched and probiotic: A focus on human health
    Zohreh Abdi-Moghadam, Majid Darroudi, Maryam Mahmoudzadeh, Mahnaz Mohtashami, Amir Mohammad Jamal, Ehsan Shamloo, Zeinab Rezaei
    Clinical Nutrition ESPEN.2023; 57: 575.     CrossRef
  • Effect of flaxseed supplementation on blood pressure: a systematic review, and dose–response meta-analysis of randomized clinical trials
    Lingou Li, Hanzhang Li, Yuzhen Gao, Somayeh vafaei, Xingyu Zhang, Mei Yang
    Food & Function.2023; 14(2): 675.     CrossRef
  • The impact of PUFA-enriched yogurt consumption on cardiovascular risk markers: A review
    Laura-Natalia Cortés, Ruby-Alejandra Villamil, Lilia-Yadira Cortés
    PharmaNutrition.2023; 23: 100330.     CrossRef
  • Availability of bioactive flax lignan from foods and supplements
    Timothy J. Tse, Yajia Guo, Youn Young Shim, Sarah K. Purdy, Ji Hye Kim, Jae Youl Cho, Jane Alcorn, Martin J. T. Reaney
    Critical Reviews in Food Science and Nutrition.2023; 63(29): 9843.     CrossRef
  • Impact of polyphenols on heart failure and cardiac hypertrophy: clinical effects and molecular mechanisms
    Neda Hedayati, Alireza Yaghoobi, Marziyeh Salami, Yasaman Gholinezhad, Farnaz Aghadavood, Reza Eshraghi, Mohammad-Hossein Aarabi, Mina Homayoonfal, Zatollah Asemi, Hamed Mirzaei, Mohammad Hajijafari, Alireza Mafi, Malihe Rezaee
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Therapeutic comparison of flex seed and black seed supplementation for treatment of type II diabetic patients
    Asra Abbas, Shahnai Basharat, Momina Shahid, Fatima Raza, Nudrat Tariq, Misbah Arshad
    Pakistan BioMedical Journal.2022; : 90.     CrossRef
  • Effect of flaxseed (Linum usitatissimum) supplementation on glycemic control and insulin resistance in prediabetes and type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials
    Andrea Isabel Villarreal-Renteria, Dulce Daniela Herrera-Echauri, Norma Patricia Rodríguez-Rocha, Laura Yareni Zuñiga, José Francisco Muñoz-Valle, Samuel García-Arellano, María Fernanda Bernal-Orozco, Gabriela Macedo-Ojeda
    Complementary Therapies in Medicine.2022; 70: 102852.     CrossRef
  • Acute Flaxseed Intake Reduces Postprandial Glycemia in Subjects with Type 2 Diabetes: A Randomized Crossover Clinical Trial
    Fernanda Duarte Moreira, Caio Eduardo Gonçalves Reis, Alexis Fonseca Welker, Andrea Donatti Gallassi
    Nutrients.2022; 14(18): 3736.     CrossRef
  • Combination therapy of flaxseed and hesperidin enhances the effectiveness of lifestyle modification in cardiovascular risk control in prediabetes: a randomized controlled trial
    Zahra Yari, Zahra Naser-Nakhaee, Elahe Karimi‐Shahrbabak, Makan Cheraghpour, Mehdi Hedayati, Seyede Marjan Mohaghegh, Shahrzad Ommi, Azita Hekmatdoost
    Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
  • Yogurts supplemented with lipid emulsions rich in omega-3 fatty acids: New insights into the fortification, microencapsulation, quality properties, and health-promoting effects
    Cansu Ekin Gumus, Seyed Mohammad Taghi Gharibzahedi
    Trends in Food Science & Technology.2021; 110: 267.     CrossRef
  • Low to no cost remedies for the management of diabetes mellitus; global health concern
    Shireen Akhter
    Journal of Diabetes & Metabolic Disorders.2021; 20(1): 951.     CrossRef
  • The role of yoghurt consumption in the management of type II diabetes
    Amalia E. Yanni, Kleio Kartsioti, Vaios T. Karathanos
    Food & Function.2020; 11(12): 10306.     CrossRef
  • Gut Microbiota and the Metabolism of Phytoestrogens
    Spase Stojanov, Samo Kreft
    Revista Brasileira de Farmacognosia.2020; 30(2): 145.     CrossRef
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[English]
Dietary Antioxidant Intake in Relation to Semen Quality Parameters in Infertile Men: a Cross-Sectional Study
Mehran Rahimlou, Sara Sohaei, Mohammadhossein Nasr-Esfahani, Mehran Nouri
Clin Nutr Res 2019;8(3):229-237.   Published online July 25, 2019
DOI: https://doi.org/10.7762/cnr.2019.8.3.229

The
objective
of this study was to assess the association between dietary antioxidant intake and semen quality parameters in infertile men. In this cross-sectional study, dietary antioxidant intake was evaluated in 175 infertile Iranian men by a validated dish-based 106-item semi-quantitative food frequency questionnaire. Men were asked to abstain from ejaculation for at least 72 hours before sample collection. Semen parameters were assessed by a sperm counting chamber and Terminal deoxynucleotidyl transferase dUTP nick end labeling assay methods. Linear quantile regression was used to determine the associations between antioxidant nutrient intake and semen quality parameters (including total sperm count, sperm density, total motility, DNA damage and DNA fragmentation). Mean age of study participants was 32.19 ± 2.34 years. Compared with the lowest quartile, men in the highest quartile of dietary β-carotene and vitamin C intake had lower sperm DNA fragmentation index (Ptrend = 0.042 and Ptrend = 0.03, respectively). Also, dietary intake of beta-cryptoxanthin had a positive association with sperm density (Ptrend = 0.02), and dietary lutein was associated with total sperm count (Ptrend = 0.045). Dietary intake of other antioxidants did not significantly correlate with the indicators related to the quantity and quality of sperm (p > 0.05). These data suggest that dietary intake of some of the antioxidants is associated with semen related parameters.

Citations

Citations to this article as recorded by  
  • The role of diet and food supplements in infertility management in the Eastern Mediterranean Region: A narrative review
    Kassandra Said Fares, Georges Hani Abi Tayeh, Emile Roger Whaibeh, Romy Jihad Louis, Lina Yasser Jaalouk, Yara Matar Matar, Myriam Andraos Mrad
    International Journal of Reproductive BioMedicine (IJRM).2025; 23(1): 1.     CrossRef
  • The Impact of Diabetes Mellitus‐Related Oxidative Stress on Male Fertility: A Review
    Simon Mwaringa Dena, Adesola Oluwaseun Adeleye, Kutullo Mohlala, Bridget Cebisile Langa, Chinyerum Sylvia Opuwari
    Journal of Diabetes.2025;[Epub]     CrossRef
  • Strategic approaches to improve equine breeding and stud farm outcomes
    Imdad Ullah Khan, Aswin Rafif Khairullah, Asfand Yar Khan, Atta Ur Rehman, Imam Mustofa
    Veterinary World.2025; : 311.     CrossRef
  • The mechanism of oxidative stress in asthenozoospermia and antioxidant strategies: a review
    Linfeng Mo, Hongmei Wu, Mingxue Zhang, Peng Zhang, Wei Peng, Yonghua He, Feng Gao
    Frontiers in Endocrinology.2025;[Epub]     CrossRef
  • Identification of testis development-related genes by combining Iso-Seq and RNA-Seq in Zeugodacus tau
    Peipei Liu, Ziniu Li, Qiuyuan Zhang, Jiao Qiao, Chenjun Zheng, Wenping Zheng, Hongyu Zhang
    Frontiers in Cell and Developmental Biology.2024;[Epub]     CrossRef
  • Association of composite dietary antioxidant index with prevalence of stroke: insights from NHANES 1999-2018
    Tian-Qi Teng, Jing Liu, Fang-Fang Hu, Qing-Qing Li, Zhen-Zhu Hu, Yu Shi
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Female infertility and dietary antioxidant index (DAI); a case-control study
    Roya Kabodmehri, Fatemeh Sadat Hashemi Javaheri, Farkhondeh Alami, Zahra Mahmoudi, Arezoo Amjadi, Zahra Saeedirad, Saeed Omidi, Shiva Sadeghi, Mohadeseh Sadat Mousavi Hoseini, Zahra Mohamadiyan, Zahra Salimi, Hanieh Shafaei, Reyhaneh Rasekhmagham, Seyedeh
    BMC Women's Health.2023;[Epub]     CrossRef
  • Phytochemical consumption and the risk of teratozoospermia: findings from a hospital-based case–control study in China
    Jun-Qi Zhao, Jia-Le Lv, Xiao-Bin Wang, Yi-Fan Wei, Ren-Hao Guo, Xu Leng, Qiang Du, Dong-Hui Huang, Qi-Jun Wu, Bo-Chen Pan, Yu-Hong Zhao
    Human Reproduction Open.2023;[Epub]     CrossRef
  • Ascorbic acid is associated with favourable hormonal profiles among infertile males
    Matineh Rastegar Panah, Irtaza Tahir, Bibiana Garcia-Bailo, Kirk Lo, Keith Jarvi, Ahmed El-Sohemy
    Frontiers in Reproductive Health.2023;[Epub]     CrossRef
  • The Association Between Dietary Antioxidants and Semen Parameters: A Cross-Sectional Study Among Iranian Infertile Men
    Shokoofeh Talebi, Arman Arab, Nasim Sorraya
    Biological Trace Element Research.2022; 200(9): 3957.     CrossRef
  • Antioxidant Vitamins and Carotenoids Intake and the Association With Poor Semen Quality: A Cross-Sectional Analysis of Men Referring to an Italian Fertility Clinic
    Valentina De Cosmi, Fabio Parazzini, Carlo Agostoni, Stefania Noli, Sonia Cipriani, Irene La Vecchia, Stefania Ferrari, Giovanna Esposito, Francesca Bravi, Elena Ricci
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • 19 View
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  • 11 Crossref