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Case Report

Preoperative Oral Carbohydrate Loading in Pancreaticoduodenectomy

Kum-Hee Son1,3, So-Young Kim1, Yeong-Ah Cho1,3, Gyung-Ah Wie1,3, Sung-Sik Han2,3, Sang-Jae Park2,3
Clinical Nutrition Research 2016;5(3):213-218.
Published online: July 29, 2016

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Correspondence to Gyung Ah Wie. Department of Clinical Nutrition, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Korea. Tel: +82-31-920-0261, Fax: +82-31-920-0269, gawie@ncc.re.kr
• Received: July 11, 2016   • Revised: July 18, 2016   • Accepted: July 25, 2016

Copyright © 2016 The Korean Society of Clinical Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Overnight fasting before elective surgery has been the routine to reduce the risk of pulmonary aspiration. Recently, several international guidelines for preoperative fasting recommend to intake carbohydrate-containing fluids up to 2 to 3 hours before the induction of anesthesia to improve postoperative recovery. Based on the recommendations, we developed a "preoperative carbohydrate diet" provided for the preoperative patients. The purpose of this case report is to share our experience of applying preoperative carbohydrate loading prior to surgery.
  • Keywords: Preoperative carbohydrate loading; Preoperative fasting; Insulin resistance
Traditionally, overnight fasting before elective surgery has been the routine in medical practice for risk reduction of pulmonary aspiration of gastric contents [1]. But, some studies have shown that prolonged fasting does not reduce gastric contents, and instead causes an increase in patient discomfort [2, 3]. Consequently, several recent international guidelines have recommended to shorten the duration of preoperative fasting for enhancing recovery after surgery [4, 5].
Surgical trauma induces a 'stress response' which involves a series of physiologic reactions and aims to promote recovery from impaired metabolic and physiological homeostasis. It also increases the release of stress hormones and inflammatory cytokines that lead the body into a catabolic state and insulin resistance. These hormones and cytokines induce the hepatic production of glucose by gluconeogenesis and glycogenolysis, and reduce glucose uptake in peripheral tissues, thus leading to postoperative hyperglycemia. In addition, they stimulate proteolysis and lipolysis. Increased insulin resistance can be sustained for 3-4 weeks after surgery and the degree of increased insulin resistance is affected by the extent of surgery, the amount of blood loss, and the duration of preoperative fasting. Prolonged preoperative fasting induces the utilization of nutrients stored in the body, and increases patient's discomfort and anxiety. It can accelerate the release of stress hormones, thereby aggravating insulin resistance [6, 7, 8, 13].
It is well known that insulin resistance is related to delayed wound healing, increased morbidity/mortality, and prolonged hospital stay [8]. Therefore, maintaining an anabolic state before surgery and reducing of postoperative insulin resistance are very important for enhancing recovery after the surgery [6].
Several international anesthesiology societies recommend the reduction in preoperative fasting time in order to enhance recovery after the surgery. These new guidelines recommend the intake of solid foods for up to 6 hours before the induction of anesthesia and the intake of clear liquids up to 2 hours before the induction of anesthesia. Especially, Enhanced Recovery After Surgery (ERAS) Society and European Society of Anesthesiology (ESA) recommend the intake of carbohydrate-containing fluids up to 2 hours prior to surgery (Table 1) [5, 6, 9, 10, 11, 12].
Table 1

Recommendations from the Enhanced Recovery After Surgery (ERAS) of preoperative oral carbohydrate loading

Table 1
Subject Recommendation grade
Gastrectomy Strong
Pancreaticoduodenectomy Strong
Elective colonic surgery Strong
Elective rectal pelvic surgery Strong
Radical cystectomy Strong
The purposes of preoperative carbohydrate loading are to maximize glycogen storage in the body as an energy source in order to minimize subsequent degradation of body tissues and reduce insulin resistance. A suitable carbohydrate-containing drink (CHOD) should contain 12.5% maltodextrin for gastric emptying. The recommendation is to intake 100 g of carbohydrate (800 mL of CHOD) in the evening before surgery, and 50 g of carbohydrate (400 mL of CHOD) until 2 hours before surgery. Insulin levels at the time are similar to those observed after normal diet and thus, the body can maintain an anabolic state [6, 13].
Based on these recommendations, a 'preoperative CHO loading diet (Soft Fluid Diet and Soft Blended Diet)' was developed to facilitate recovery from the illness after surgery and to increase patient's satisfaction in the National Cancer Center. The purpose of this case report is to share our experience of applying a preoperative carbohydrate loading prior to surgery.
A 'preoperative CHO loading diet' was given to patients scheduled to undergo hepatobiliary-pancreatic (HBP) surgery, including pancreaticoduodenectomy, for which surgery CHO loading is strongly recommended by the ERAS program. To evaluate the effect of preoperative carbohydrate loading on clinical outcome, it was necessary to estimate several factors including gastric residual volumes (GRV) before surgery, nutritional factors, subjective well-being, and insulin resistance. This study was approved by the Institutional Review Board of the National Cancer Center (NCC 2016-0104).
A 52-year-old man was diagnosed with cancer of the common bile duct and admitted into the National Cancer Center for pancreaticoduodenectomy. The patient's height was 166.4 cm, body weight was 67.0 kg, body mass index was 24.2 kg/m2. The patient did not have any underlying disease, including diabetes mellitus or gastro-esophageal reflux disease. Surgery was scheduled for 09:00 AM on the following morning.
Preoperative day #1
A registered dietitian assessed the patient's nutritional status using the scored Patient-Generated Subjective Global Assessment (PG-SGA), the patient was classified as moderate malnourition (SGA-B) due to weight loss and reduced food intake owing to abdominal discomfort. Also, a registered dietitian explained to the patient about the diet protocol, including CHOD before surgery (Table 2). The patient consumed the entire of 'preoperative CHO loading diet (SBD)' without any problems. Nutrient facts of provided CHOD were recorded in the Table 3.
Table 2

Preoperative carbohydrate loading protocol

Table 2
Preoperative day #1 Operative day
Diet - Lunch: regular diet - Breakfast: preoperative CHO diet (SFD)† up to 05:30 AM
- Dinner: preoperative CHO diet (SBD)*
CHO, carbohydrate; SBD, soft blended diet; SFD, soft fluid diet.
*100 mL of rice porridge with 800 mL of carbohydrate-containing drink; †400 mL of carbohydrate-containing drink.
Table 3

Nutrition facts of carbohydrate drink

Table 3
Nutrients Composition per 100 mL
Energy 50 kcal
Carbohydrate 12.8 g
Sugar 2 g
Protein 0 g
Fat 0 g
Saturated fatty acid 0 g
Trans fatty acid 0 g
Cholesterol 0 mg
Sodium 52 mg
Potassium 48 mg
Operative day
On the day of surgery, the patient was given the 'preoperative CHO loading diet (SFD)' including 400 mL of CHOD and allowed to drink this until 05:30 AM. He was asked to score his subjective well-being with the 10 cm visual analog scale (VAS) prior to surgery. The patient's subjective well-being scores were as follows: thirst-2; hunger-3; comfort-5; anxiety-1; fatigue-2.
Plasma glucose and insulin concentrations were measured and homeostatic model assessment-insulin resistance (HOMA-IR) was calculated in order to determine insulin resistance before the surgery. Plasma glucose and insulin concentrations were 112 mg/dL and, 8.2 µU/mL, respectively, while HOMA-IR was 2.27. Gastric residual volume (GRV) was measured preoperatively via L-tube aspiration.
The patient consumed 400 mL of CHOD up to 4 hours before surgery and GRV was 5 mL. Following the surgery, the patient was sent to the surgical intensive care unit and received postoperative medical care for pancreaticoduodenectomy.
Postoperative day #1
The patient was provided with routine postoperative care. In the morning, the patient's plasma glucose and insulin concentrations were 187 mg/dL and 4.8 µU/mL, respectively, and HOMA-IR was 2.22 (Table 4). Compared to the day of surgery, the HOMA-IR on postoperative day #1 had not been increased. The patient was sent to a general ward later that afternoon.
Table 4

Factors related to insulin resistance

Table 4
Variables Operative day Postoperative day #1
Glucose, mg/dL 112 187
Insulin, µU/mL 8.2 4.8
HOMA-IR* 2.27 2.22
HOMA IR, homeostatic model assessment-insulin resistance.
*HOMA-IR = [plasma insulin (µU/mL) × plasma glucose (mmoL/L)] / 22.5.
Discharge
The patient received 'post-pancreaticoduodenectomy diet' and was recovered well in the general ward without any complications. The patient was discharged 14 days after the surgery and body weight was 61.2 kg.
Many recent studies have shown that preoperative carbohydrate loading does not influence gastric residuals and reduces patient discomfort [2, 16]. Moreover, it has been shown to be effective in reducing insulin resistance [13]. Jonas et al. [2] reported no difference in gastric residue two hours after drinking 400 mL of a 12.5% carbohydrate drink when compared to an equivalent volume of water. Yuill et al. [14] showed that the decrease in muscle mass after upper gastrointestinal surgery in preoperative carbohydrate loading group was less than that in fasting group. Noblett et al. [15] also reported enhanced recovery of a hand grip strength and a reduced length of hospital stay in patients with colectomy after preoperative carbohydrate loading. According to a recent Cochrane review, preoperative well-being and postoperative nausea and fatigue were improved after preoperative carbohydrate loading. The case in our hospital showed almost no gastric residual volume and low scores of patient discomfort including thirst and hunger after preoperative oral carbohydrate loading.
After surgery, blood glucose levels are increased due to the decrease in insulin secretion, and insulin resistance is also increased in response to stress. The mechanisms by which preoperative CHO loading attenuates postoperative insulin resistance are still unclear. But, some studies showed that preoperative carbohydrate loading can reduce insulin resistance by glucose uptake in the muscle due to insulin secretion [3, 18]. Fujikuni et al. [17] showed that the postoperative insulin resistance in patients with gastrectomy was decreased by preoperative carbohydrate loading compared with fasting. In this patient, insulin resistance did not increase, presumably due to preoperative oral carbohydrate loading.
Therefore, we think that preoperative oral carbohydrate loading may be helpful for the recovery of patients. Currently, preoperative oral carbohydrate loading is only recommended to patients undergoing hepato-biliary-pancratic surgery at our hospital, but we are on the research for the application of preoperative oral carbohydrate loading to the patients with other cancers. However, there are almost no studies on the amount of CHOD intake for Korean subjects. Hence, further studies should be conducted in this field.

Conflict of Interest: The authors have no potential conflicts of interest to disclose.

  • 1. Boyle HE, Hewer CL. Practical anaesthetics. 3rd ed. London: Frowde, Hodder and Stoughton; 1923.
  • 2. Nygren J, Thorell A, Jacobsson H, Larsson S, Schnell PO, Hylén L, Ljungqvist O. Preoperative gastric emptying. Effects of anxiety and oral carbohydrate administration. Ann Surg 1995;222:728-734.
  • 3. Ljungqvist O. Modulating postoperative insulin resistance by preoperative carbohydrate loading. Best Pract Res Clin Anaesthesiol 2009;23:401-409.
  • 4. Smith I, Kranke P, Murat I, Smith A, O'Sullivan G, Søreide E, Spies C, in't Veld B; European Society of Anaesthesiology. Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2011;28:556-569.
  • 5. Lassen K, Coolsen MM, Slim K, Carli F, de Aguilar-Nascimento JE, Schäfer M, Parks RW, Fearon KC, Lobo DN, Demartines N, Braga M, Ljungqvist O, Dejong CH, Cornelis H; ERAS® Society; European Society for Clinical Nutrition and Metabolism; International Association for Surgical Metabolism and Nutrition. Guidelines for perioperative care for pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations. Clin Nutr 2012;31:817-830.
  • 6. Gillis C, Carli F. Promoting perioperative metabolic and nutritional care. Anesthesiology 2015;123:1455-1472.
  • 7. Ljungqvist O, Efendic S, Eneroth P, Hamberger B, Nylander G, Ware J. Nutritional status and endocrine response to hemorrhage. Can J Physiol Pharmacol 1986;64:1185-1188.
  • 8. Ljungqvist O, Soop M, Hedström M. Why metabolism matters in elective orthopedic surgery: a review. Acta Orthop 2007;78:610-615.
  • 9. Mortensen K, Nilsson M, Slim K, Schäfer M, Mariette C, Braga M, Carli F, Demartines N, Griffin SM, Lassen K; Enhanced Recovery After Surgery (ERAS®) Group. Consensus guidelines for enhanced recovery after gastrectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations. Br J Surg 2014;101:1209-1229.
  • 10. Gustafsson UO, Scott MJ, Schwenk W, Demartines N, Roulin D, Francis N, McNaught CE, Macfie J, Liberman AS, Soop M, Hill A, Kennedy RH, Lobo DN, Fearon K, Ljungqvist O; Enhanced Recovery After Surgery (ERAS) Society, for Perioperative Care; European Society for Clinical Nutrition and Metabolism (ESPEN); International Association for Surgical Metabolism and Nutrition (IASMEN). Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. World J Surg 2013;37:259-284.
  • 11. Nygren J, Thacker J, Carli F, Fearon KC, Norderval S, Lobo DN, Ljungqvist O, Soop M, Ramirez J; Enhanced Recovery After Surgery (ERAS) Society, for Perioperative Care; European Society for Clinical Nutrition and Metabolism (ESPEN); International Association for Surgical Metabolism and Nutrition (IASMEN). Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. World J Surg 2013;37:285-305.
  • 12. Cerantola Y, Valerio M, Persson B, Jichlinski P, Ljungqvist O, Hubner M, Kassouf W, Muller S, Baldini G, Carli F, Naesheimh T, Ytrebo L, Revhaug A, Lassen K, Knutsen T, Aarsether E, Wiklund P, Patel HR. Guidelines for perioperative care after radical cystectomy for bladder cancer: Enhanced Recovery After Surgery (ERAS(®)) society recommendations. Clin Nutr 2013;32:879-887.
  • 13. Soop M, Nygren J, Myrenfors P, Thorell A, Ljungqvist O. Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin resistance. Am J Physiol Endocrinol Metab 2001;280:E576-83.
  • 14. Yuill KA, Richardson RA, Davidson HI, Garden OJ, Parks RW. The administration of an oral carbohydrate-containing fluid prior to major elective upper-gastrointestinal surgery preserves skeletal muscle mass postoperatively--a randomised clinical trial. Clin Nutr 2005;24:32-37.
  • 15. Noblett SE, Watson DS, Huong H, Davison B, Hainsworth PJ, Horgan AF. Pre-operative oral carbohydrate loading in colorectal surgery: a randomized controlled trial. Colorectal Dis 2006;8:563-569.
  • 16. Smith MD, McCall J, Plank L, Herbison GP, Soop M, Nygren J. Preoperative carbohydrate treatment for enhancing recovery after elective surgery. Cochrane Database Syst Rev 2014;CD009161.
  • 17. Fujikuni N, Tanabe K, Tokumoto N, Suzuki T, Hattori M, Misumi T, Ohdan H. Enhanced recovery program is safe and improves postoperative insulin resistance in gastrectomy. World J Gastrointest Surg 2016;8:382-388.
  • 18. Svanfeldt M, Thorell A, Hausel J, Soop M, Rooyackers O, Nygren J, Ljungqvist O. Randomized clinical trial of the effect of preoperative oral carbohydrate treatment on postoperative whole-body protein and glucose kinetics. Br J Surg 2007;94:1342-1350.

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Preoperative Oral Carbohydrate Loading in Pancreaticoduodenectomy
Clin Nutr Res. 2016;5(3):213-218.   Published online July 29, 2016
DOI: https://doi.org/10.7762/cnr.2016.5.3.213
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Preoperative Oral Carbohydrate Loading in Pancreaticoduodenectomy
Clin Nutr Res. 2016;5(3):213-218.   Published online July 29, 2016
DOI: https://doi.org/10.7762/cnr.2016.5.3.213
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Preoperative Oral Carbohydrate Loading in Pancreaticoduodenectomy
Preoperative Oral Carbohydrate Loading in Pancreaticoduodenectomy
Table 1 Recommendations from the Enhanced Recovery After Surgery (ERAS) of preoperative oral carbohydrate loading
Table 2 Preoperative carbohydrate loading protocol

CHO, carbohydrate; SBD, soft blended diet; SFD, soft fluid diet.

*100 mL of rice porridge with 800 mL of carbohydrate-containing drink; †400 mL of carbohydrate-containing drink.

Table 3 Nutrition facts of carbohydrate drink
Table 4 Factors related to insulin resistance

HOMA IR, homeostatic model assessment-insulin resistance.

*HOMA-IR = [plasma insulin (µU/mL) × plasma glucose (mmoL/L)] / 22.5.

Table 1

Table 2

Table 3

Table 4

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