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Original Article

Association between Genetic Variations Affecting Mean Telomere Length and the Prevalence of Hypertension and Coronary Heart Disease in Koreans

Jean Kyung Paik1orcid, Ryungwoo Kang2orcid, Yoonsu Cho3orcid, Min-Jeong Shin3orcid
Clinical Nutrition Research 2016;5(4):249-260.
Published online: October 31, 2016

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Correspondence to Min-Jeong Shin. Department of Public Health Sciences, BK21PLUS Program in Embodiment: Health-Society Interaction, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea. Tel: +82-2-3290-5643, Fax: +82-2-940-2849, mjshin@korea.ac.kr
• Received: October 5, 2016   • Revised: October 12, 2016   • Accepted: October 15, 2016

Copyright © 2016 The Korean Society of Clinical Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Association between Genetic Variations Affecting Mean Telomere Length and the Prevalence of Hypertension and Coronary Heart Disease in Koreans
Clin Nutr Res. 2016;5(4):249-260.   Published online October 31, 2016
DOI: https://doi.org/10.7762/cnr.2016.5.4.249
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Association between Genetic Variations Affecting Mean Telomere Length and the Prevalence of Hypertension and Coronary Heart Disease in Koreans
Clin Nutr Res. 2016;5(4):249-260.   Published online October 31, 2016
DOI: https://doi.org/10.7762/cnr.2016.5.4.249
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Association between Genetic Variations Affecting Mean Telomere Length and the Prevalence of Hypertension and Coronary Heart Disease in Koreans
Image
Figure 1 Association between disease prevalence and telomere related genotypes according to alcohol status. The forest plot was based on estimates from logistic regressions after adjustment for sex, age, area, body mass index, education level, physical activity, and smoking. In case of analysis within the non-alcohol users, previous alcohol use was additionally included in the regression model. *Indicated statistical significance at level of p < 0.05.

Figure 1

Association between Genetic Variations Affecting Mean Telomere Length and the Prevalence of Hypertension and Coronary Heart Disease in Koreans
Table 1 Baseline characteristics of the subjects

SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; WC, waist circumference; FBG, fasting blood glucose; TC, total cholesterol; HDLC, high density lipoprotein cholesterol; LDLC, low density lipoprotein cholesterol; TG, triglycerides; γ-GTP, gamma-glutamyl transpeptidase; hs-CRP, high sensitivity C reactive protein; n, number.

*Values are represented as mean ± standard error for continuous variables and number of counts and percentage for categorical variables. †p values are from student’s t-test for continuous variables and χ2 test for categorical variables assessing the difference between the groups. ‡Apart from major dependent variables (e.g. hypertension and coronary heart disease) and major independent variables (e.g. genotype), some variables included missing data points. §The values were represented as percentage of the AA / Aa / aa genotype, respectively.

Table 2 Available reported SNPs and their association with telomere length related SNP and disease prevalence

SNP, single nucleotide polymorphism; OA, other allele; MA, minor allele; MAF, minor allele frequencies; OR, odds ratio; CI, confidence interval.

*Effect size is described with ORs are described with 95% CI and p value at a 0.05 significance level for each SNPs. †Differences were tested using logistic regression model for disease prevalence after adjusting for sex, age, area, body mass index, education level, physical activity, smoking, and drinking.

Table 3 Difference of biochemical markers among the subjects according to telomere related genotype

SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; WC, waist circumference; FBG, fasting blood glucose; TC, total cholesterol; HDLC, high density lipoprotein cholesterol; LDLC, low density lipoprotein cholesterol; TG, triglycerides; γ-GTP, gamma-glutamyl transpeptidase; hs-CRP, high sensitivity C reactive protein.

*Estimates are presented as regression coefficient β, 95% confidence interval (CI). Corresponding p values were provided separately. These estimates were obtained from linear regression regressions with an ordinary least squares estimation method. All regression models were adjusted for sex, age, area, body mass index, education level, physical activity, smoking, and drinking. †Values were used in statistical model after log-transformation to satisfy the assumption of normal distribution.

Table 1

Table 2

Table 3

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