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Review Article

Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior

Danbi Jo1,2orcid, Juhyun Song1,2orcid
Clinical Nutrition Research 2021;10(4):292-302.
Published online: October 20, 2021

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Correspondence to Juhyun Song. Department of Anatomy, Chonnam National University Medical School, 264 Seoyang-ro, Hwasun-eup, Hwasun 58128, Korea. juhyunsong@chonnam.ac.kr
• Received: August 15, 2021   • Revised: September 9, 2021   • Accepted: September 9, 2021

Copyright © 2021. The Korean Society of Clinical Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior
Clin Nutr Res. 2021;10(4):292-302.   Published online October 20, 2021
DOI: https://doi.org/10.7762/cnr.2021.10.4.292
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Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior
Clin Nutr Res. 2021;10(4):292-302.   Published online October 20, 2021
DOI: https://doi.org/10.7762/cnr.2021.10.4.292
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Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior
Image
Figure 1 Schematic images showing the effects of irisin on PGC-1α and BDNF pathways. In central nervous system, irisin plays multiple roles to improve mitochondria function through PGC-1α signaling and to enhance synaptic plasticity through BDNF signaling in neurons, leading to the improvement of depressive neuropathology.CTF, C-terminal fragment; MD, membrane domain; FNDC5, fibronectin domain-containing protein 5; PGC-1α, proliferator-activated receptor-gamma coactivator-1 alpha; UCP1, uncoupling protein one; BDNF, brain-derived neurotrophic factor; TrkB, tropomyosin receptor kinase B.

Figure 1

Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior
CNR : Clinical Nutrition Research

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