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"ERAS"

Original Articles

[English]
Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Mohammad Reza Amini, Fatemeh Sheikhhossein, Alireza Talebyan, Elham Bazshahi, Farhang Djafari, Azita Hekmatdoost
Clin Nutr Res 2022;11(3):228-239.   Published online July 25, 2022
DOI: https://doi.org/10.7762/cnr.2022.11.3.228

Studies examining the effect of artichoke on liver enzymes have reported inconsistent results. This systematic review and meta-analysis aimed to assess the effects of artichoke administration on the liver enzymes. PubMed, Embase, the Cochrane Library, and Scopus databases were searched for articles published up to January 2022. Standardized mean difference (Hedges’ g) were analyzed using a random-effects model. Heterogeneity, publication bias, and sensitivity analysis were assessed for the liver enzymes. Pooled analysis of seven randomized controlled trials (RCTs) suggested that the artichoke administration has an effect on both alanine aminotransferase (ALT) (Hedges’ g, −1.08; 95% confidence interval [CI], −1.76 to −0.40; p = 0.002), and aspartate aminotransferase (AST) (Hedges’ g, −1.02; 95% CI, −1.76 to −0.28; p = 0.007). Greater effects on ALT were detected in trials that lasted ≤8 weeks. Also, greater effects on AST were detected in trials using > 500 mg artichoke. Overall, this meta-analysis demonstrated artichoke supplementation decreased ALT and AST.

Citations

Citations to this article as recorded by  
  • Artichoke and cardiometabolic health: A systematic and meta-analytic synthesis of current evidence
    Ali Jafari, Mohammad Amin Karimi, Mahsa Mahmoudinezhad, Fatemeh Razavi, Helia Mardani, Vali Musazadeh
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2025; 19(10): 103328.     CrossRef
  • The Green Path to Liver Health: Herbal Solutions for Non-alcoholic Steatohepatitis
    Shubham Sharma, Anjali Sharma, Parul Gupta, Deepshi Arora, Geeta Deswal, Ajmer Grewal, Devkant Sharma
    Cardiovascular & Hematological Disorders-Drug Targets.2025; 25(3): 168.     CrossRef
  • Artichoke leaf extract reduces steatosis and decreases liver size in prebariatric patients: A randomized placebo-controlled pilot trial—The “SteatoChoke-Study”
    Sebastian Holländer, Evelyn Marth, Philipp Robert Scherber, Antonios Spiliotis, Ammar Al-Ali, Gereon Gäbelein, Matthias Glanemann
    Journal of Clinical Lipidology.2025;[Epub]     CrossRef
  • Relato de Caso: Alergias e Intolerâncias Alimentares na Prática de Consultório
    Karla Raissa Ferreira de Carvalho, Niraldo Paulino, Gabriela Cicalise de Souza Santos, Joycelene Ribeiro Viana Movilha, Vanessa Carolina Costa Amaral, Amanda Magalhães das Neves, Érica da Silva Romão Cassiano
    Revista de Gestão e Secretariado.2025; 16(10): e5300.     CrossRef
  • In‐depth assessment of steatotic liver disease awareness in high‐risk groups
    Murat Özdede, Alper Tuna Güven, Burcu Çelik Eroğlu
    Journal of Evaluation in Clinical Practice.2025;[Epub]     CrossRef
  • An Overview of the Versatility of the Parts of the Globe Artichoke (Cynara scolymus L.), Its By-Products and Dietary Supplements
    Beata Olas
    Nutrients.2024; 16(5): 599.     CrossRef
  • Bioactive Compounds, Health Benefits and Food Applications of Artichoke (Cynara scolymus L.) and Artichoke By-Products: A Review
    Pablo Ayuso, Jhazmin Quizhpe, María de los Ángeles Rosell, Rocío Peñalver, Gema Nieto
    Applied Sciences.2024; 14(11): 4940.     CrossRef
  • Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
    Chiara Porro, Tarek Benameur, Antonia Cianciulli, Mirco Vacca, Margherita Chiarini, Maria De Angelis, Maria Antonietta Panaro
    Nutrients.2024; 16(6): 872.     CrossRef
  • Medicinal Plant-derived Phytochemicals in Detoxification
    Geir Bjørklund, Natália Cruz-Martins, Bey Hing Goh, Olha Mykhailenko, Roman Lysiuk, Mariia Shanaida, Larysa Lenchyk, Taras Upyr, Marius Emil Rusu, Antonina Pryshlyak, Volodymyr Shanaida, Salvatore Chirumbolo
    Current Pharmaceutical Design.2024; 30(13): 988.     CrossRef
  • From Scraps to Solutions: Harnessing the Potential of Vegetable and Fruit Waste in Pharmaceutical Formulations
    Vishnu Mittal, Anjali Sharma
    Letters in Functional Foods.2024;[Epub]     CrossRef
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[English]
Genetic Variations in Thiamin Transferase SLC35F3 and the Risk of Hypertension in Koreans
Ja-young Seo, Jeong-Hwa Choi
Clin Nutr Res 2021;10(2):140-149.   Published online April 19, 2021
DOI: https://doi.org/10.7762/cnr.2021.10.2.140

Hypertension is a major health issues globally. Multiple genetic and environmental factors are involved in hypertension etiology. Solute carrier family 35 member F3 (SLC35F3) is a type of transporter uptakes thiamin across the cellular and mitochondrial membrane. Recent studies suggested that variations in SLC35F3 are associated with the risk of hypertension; however, studies are limited in Koreans. This study examined the association of the genetic variations in SLC35F3 and the risk of hypertension in Koreans using the Korean Genome Epidemiology Study (Ansan/Ansung study). A total of 8,298 Koreans (males 3,983, females 4,315) were analyzed for their general characteristics, dietary intake, and blood pressure. Twenty-four tagging variations in SLC35F3 were selected and investigated for their association with the risk of hypertension using a sex-stratified approach. Findings suggested that, in males, rs12135117 A allele carriers were at the lower risk for hypertension (adjusted odds ratio, 0.859; 95% confidence interval [CI], 0.740–0.998). In females, rs10910387 TC genotype tended to increase the risk 1.172-fold for hypertension (95% CI, 1.002–1.370). Multiple linear regression models exhibited that rs12135117 A allele was negatively associated with blood pressure in males, and rs10910387 TC genotype had a positive association with blood pressure in females. However, statistical significance for these genetically modified effects was in lacked (Bonferroni's corrected p > 0.002). In conclusion, genetic variation in SLC35F3 is not a decisive prediction marker for hypertension risk in Koreans. Given the rarity of data, more studies are required to evaluate the role of SLC35F3 and thiamin in the hypertension etiology.

Citations

Citations to this article as recorded by  
  • Modeling genotype-by-environment interactions across climatic conditions reveals environment-specific genomic regions and candidate genes underlying feed efficiency traits in tropical beef cattle
    João B. Silva Neto, Luiz F. Brito, Lucio F. M. Mota, Gustavo R. D. Rodrigues, Fernando Baldi
    Scientific Reports.2026;[Epub]     CrossRef
  • SLC35 Transporters: The Missing Link Between Glycosylation and Type 2 Diabetes
    Xu Zhang, Hafiza Mahreen Mehwish, Pulin Che
    Diabetology.2026; 7(1): 7.     CrossRef
  • RNA-seq analysis identifies key genes enhancing hoof strength to withstand barefoot racing in Standardbred trotters
    Doreen Schwochow, Asmaa Alameddine, Ellinor Spörndly-Nees, Mathilde Montigny, Rakan Naboulsi, Anna Jansson, Adnan Niazi, Gabriella Lindgren
    BMC Genomics.2025;[Epub]     CrossRef
  • Scoping review of research trends in genetic factors related to metabolic syndrome in Koreans: using the data from Korean Genome and Epidemiology Study (KoGES)
    Minyeong Kim, Subin Kim, Dayeon Shin
    Journal of Nutrition and Health.2025; 58(1): 131.     CrossRef
  • Associations of Serum Thiamine Levels with Blood Pressure Among Middle-Aged and Elderly Women in Eastern China
    Lijin Chen, Jingjing Lin, Xiangyu Chen, Zhimin Ma, Xiaofu Du, Meng Wang, Rong Chen, Jieming Zhong
    Nutrients.2025; 17(13): 2210.     CrossRef
  • The construction of a novel prognostic prediction model for glioma based on GWAS-identified prognostic-related risk loci
    Jie Wei, Yujie Li, Wenqian Zhou, Xiaoya Ma, Jie Hao, Ting Wen, Bin Li, Tianbo Jin, Mingjun Hu
    Open Medicine.2024;[Epub]     CrossRef
  • Unveiling the Enigmatic Role of SLC35F3 in Lung Adenocarcinoma
    Yiwang Ye, Feihu Long, Wei Yue, Zichun Wei, Jianyi Yang, Yuancai Xie
    The Clinical Respiratory Journal.2024;[Epub]     CrossRef
  • Solute Carrier Family 35 (SLC35)—An Overview and Recent Progress
    Shin Kamiyama, Hideyuki Sone
    Biologics.2024; 4(3): 242.     CrossRef
  • Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next-generation sequencing data analysis
    Basavaraj Vastrad, Chanabasayya Vastrad
    Egyptian Journal of Medical Human Genetics.2024;[Epub]     CrossRef
  • Effects of Interaction between SLC35F3 and Carbohydrate Intake on the Incidence of Metabolic Syndrome in Korean Middle-Aged Adults
    Haeun Park, Dayeon Shin
    Nutrients.2023; 15(2): 469.     CrossRef
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[English]
The Effects of Nigella sativa Supplementation on Liver Enzymes Levels: a Systematic Review and Meta-analysis of Randomized Controlled Trials
Neda Azizi, Mohammad Reza Amini, Kurosh Djafarian, Sakineh Shab-Bidar
Clin Nutr Res 2021;10(1):72-82.   Published online January 29, 2021
DOI: https://doi.org/10.7762/cnr.2021.10.1.72

The present systematic review and meta-analysis aimed to investigate the effects of Nigella sativa (N. sativa) supplementation on liver enzymes levels including aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Relevant studies, published from inception up to January 2020, were searched through PubMed, Scopus and Google Scholar conducted on randomized controlled trials (RCTs) investigating the effect of N. sativa on serum AST and ALT levels. Meta-analysis was applied using a random-effects model. Eight studies met inclusion criteria (n=281 in the N. sativa and n = 279 in placebo group). This meta-analysis showed that N. sativa supplementation significantly reduced AST level (weighted mean difference [WMD], −8.11 IU/L; 95% confidence interval [CI], −13.6, −2.53; p = 0.004) with significant heterogeneity (I-squared, 95.9%; p < 0.001) while the decrease in ALT level was not statistically significant (WMD, −7.26 IU/L; 95% CI, −15.4, 0.04; p = 0.051) with significant heterogeneity (I-squared, 97.8%; p < 0.001). This meta-analysis suggests that N. sativa supplementation may improve AST levels and ALT levels, however more RCTs with larger sample size are needed to found effects of N. sativa on liver enzymes in patients with non-alcoholic fatty liver disease.

Citations

Citations to this article as recorded by  
  • Clinical and In vitro Data Shed New Light on the Therapeutic Advantages of Black Seeds (Nigella sativa) for the Treatment of Hepatitis C and Hepatitis B Viral Infections
    Naina Mohamed Pakkir Maideen, Rajkapoor balasubramanian, Kumar Balasubramanian, Mohamed Harsath Jahir Hussain, Mohamed Fahath Shahul Hameed, Rethesh Senthil
    Infectious Disorders - Drug Targets.2025;[Epub]     CrossRef
  • The effect of plant growth regulators, FeO3-CTs nanoparticles and LEDs light on the growth and biochemical compounds of black seed (Nigella sativa L.) callus in vitro
    Ali Sobhannizadeh, Mousa Torabi Giglou, Mahdi Behnamian, Asghar Estaji, Mohammad Majdi, Antoni Szumny
    BMC Plant Biology.2025;[Epub]     CrossRef
  • Effects of black seed (Nigella sativa L.) on cardiometabolic indices in type 2 diabetic patients: A systematic review and meta-analysis of RCTs
    Mehdi Karimi, Samira Pirzad, Seyed Morteza Ali Pourfaraji, Fatemeh Maleki Sedgi, Bahar Darouei, Reza Amani-Beni, Kimia Kazemi, Reyhaneh Rabiee
    Complementary Therapies in Medicine.2025; 90: 103174.     CrossRef
  • The protective effect of various forms of Nigella sativa against hepatorenal dysfunction: underlying mechanisms comprise antioxidation, anti- inflammation, and anti-apoptosis
    Reham M. Algheshairy, Hend F. Alharbi, Mona S. Almujaydil, Raghad M. Alhomaid, Hoda A. Ali
    Frontiers in Nutrition.2025;[Epub]     CrossRef
  • Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials
    Ali Jafari, Helia Mardani, Amir Hossein Faghfouri, Zahra Mirzaei Fashtali, Mohtaram Hashemi, Matin Abdollahi Yousefabady, Reihane Javid, Sahar Golabi, Bahareh Arghavan, Vali Musazadeh, Mahshid Naghashpour
    Pharmacological Research.2025; 219: 107882.     CrossRef
  • Polycystic ovary syndrome and its management: In view of oxidative stress
    Koushik Bhattacharya, Rajen Dey, Debanjana Sen, Nimisha Paul, Asim Kumar Basak, Mohuya Patra Purkait, Nandini Shukla, Gargi Ray Chaudhuri, Aniruddha Bhattacharya, Rajkumar Maiti, Krishnendu Adhikary, Prity Chatterjee, Prithviraj Karak, Alak Kumar Syamal
    Biomolecular Concepts.2024;[Epub]     CrossRef
  • Immune stimulatory effect of Nigella sativa in healthy animal models: A systematic review and meta-analysis
    Abdulsamad Alsalahi, Nian N.N. Maarof, Mohammed A. Alshawsh, Musheer A. Aljaberi, Mousa A. Qasem, Abdulaleem Mahuob, Nassrin A. Badroon, Ebthag A.M. Mussa, Rukman A. Hamat, Atiyah M. Abdallah
    Heliyon.2024; 10(6): e27390.     CrossRef
  • Nigella sativa and health outcomes: An overview of systematic reviews and meta-analyses
    Zhongyu Li, Yang Wang, Qing Xu, Jinxin Ma, Xuan Li, Jiaxing Yan, Yibing Tian, Yandong Wen, Ting Chen
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Effect of Nigella sativa on Selected Gastrointestinal Diseases
    Sara Jarmakiewicz-Czaja, Magdalena Zielińska, Kacper Helma, Aneta Sokal, Rafał Filip
    Current Issues in Molecular Biology.2023; 45(4): 3016.     CrossRef
  • Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review
    Małgorzata Szczuko, Justyna Kikut, Urszula Szczuko, Iwona Szydłowska, Jolanta Nawrocka-Rutkowska, Maciej Ziętek, Donatella Verbanac, Luciano Saso
    Nutrients.2021; 13(7): 2452.     CrossRef
  • The effect of nanomicelle curcumin supplementation and Nigella sativa oil on the expression level of miRNA‐21, miRNA‐422a, and miRNA‐503 gene in postmenopausal women with low bone mass density: A randomized, triple‐blind, placebo‐controlled clinical trial
    Azizeh Farshbaf‐Khalili, Safar Farajnia, Samira Pourzeinali, Seyed Kazem Shakouri, Hanieh Salehi‐Pourmehr
    Phytotherapy Research.2021; 35(11): 6216.     CrossRef
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Case Report
[English]
Diet Modification Based on the Enhanced Recovery After Surgery Program (ERAS) in Patients Undergoing Laparoscopic Colorectal Resection
Ji Yeon Kim, Gyung Ah Wie, Yeong Ah Cho, So Young Kim, Dae Kyung Sohn, Suk Kyoung Kim, Mee Duck Jun
Clin Nutr Res 2018;7(4):297-302.   Published online October 29, 2018
DOI: https://doi.org/10.7762/cnr.2018.7.4.297

The enhanced recovery after surgery (ERAS) program aims to maximize the recovery of patients by minimizing pre- and postoperative complications and stress. The program recommends providing preoperative carbohydrate (CHO) supplements and starting an early postoperative diet to reduce the fasting duration. Based on these recommendations, we implemented preoperative CHO supplementation and initiated an early postoperative diet in patients undergoing laparoscopic colorectal resection. We observed 3 patients as follows: a non-ERAS case, preoperative ERAS case, and pre- and postoperative ERAS case. The preoperative well-being and compliance of patients improved after implementation of the ERAS program. Moreover, the length of hospital stay was reduced. Therefore, we consider that the ERAS program may be helpful for the recovery of patients undergoing laparoscopic colorectal resection.

Citations

Citations to this article as recorded by  
  • Empfehlungen zur operativen Therapie der tief infiltrierenden Endometriose des Rektums
    Stefan Rimbach, Franz Bitto, Peter Busch, Radek Chvatal, Simon Keckstein, Sebastian Schäfer, Min-Seop Son, Cloé Vaineau, Martin Sillem
    Geburtshilfe und Frauenheilkunde.2025; 85(03): 253.     CrossRef
  • Comparative analysis of short- and long-term outcomes in laparoscopic versus open surgery for colorectal cancer patients undergoing hemodialysis
    Hsin-Yuan Hung, Shu-Huan Huang, Tzong-yun Tsai, Jeng-Fu You, Pao-Shiu Hsieh, Cheng-Chou Lai, Wen-Sy Tsai, Kun-Yu Tsai
    Langenbeck's Archives of Surgery.2024;[Epub]     CrossRef
  • Enhanced recovery after surgery in thulium laser prostatectomy: benefits and complication risk factors
    Xiaoxiao Xu
    American Journal of Translational Research.2024; 16(9): 4950.     CrossRef
  • Morning or Afternoon Scheduling for Elective Coronary Artery Bypass Surgery: Influence of Longer Fasting Periods from Metabolic and Hemodynamic Perspectives
    Cristina Santonocito, Cesare Cassisi, Federica Chiarenza, Alessandro Caruso, Paolo Murabito, Marc O. Maybauer, Shane George, Filippo Sanfilippo
    Annals of Cardiac Anaesthesia.2024; 27(2): 136.     CrossRef
  • Cerrahi Süreçte Hasta Beslenmesinde Güncel Yaklaşımlar
    Elife KETTAŞ DÖLEK, Sevilay ERDEN
    Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi.2023; 18(1): 183.     CrossRef
  • Postoperative inpatient exercise facilitates recovery after laparoscopic surgery in colorectal cancer patients: a randomized controlled trial
    Jihee Min, Ki-yong An, Hyuna Park, Wonhee Cho, Hye Jeong Jung, Sang Hui Chu, Minsoo Cho, Seung Yoon Yang, Justin Y. Jeon, Nam Kyu Kim
    BMC Gastroenterology.2023;[Epub]     CrossRef
  • Impact of preoperative pharmaceutical care consultation on medication errors in surgical patients: a comprehensive analysis
    Daniel Gomez Costas, Almudena Ribed Sánchez, Alvaro Gimenez Manzorro, Ignacio Garutti Martinez, Francisco Javier Sanz Fernandez, Beatriz Torroba Sanz, Sergio Herrero Bermejo, Ana María Herranz-Alonso, María Sanjurjo
    Expert Opinion on Drug Safety.2023; 22(12): 1301.     CrossRef
  • Cerrahi Sonrası Hızlandırılmış İyileşme (Eras) Protokolleri Çerçevesinde Cerrahi Hastasında Malnütrisyon
    Şerife Naz BOZDOĞAN, Sema KOÇAŞLI
    Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi.2022; 5(2): 85.     CrossRef
  • DYNAMICS OF PHOSPHATE LEVEL AND ADAPTATION POTENTIAL IN THE IMPLEMENTATION OF THE ERAS-PROTOCOL IN OVERWEIGHT PATIENTS WITH A SURGICAL PROFILE
    Dyachenko Hlib Dmytrovych, Volkova Yuliya
    World Science.2020;[Epub]     CrossRef
  • Enhanced recovery after surgery and practical application to liver transplantation
    M. Susan Mandell, Jiapeng Huang, Jing Zhao
    Best Practice & Research Clinical Anaesthesiology.2020; 34(1): 119.     CrossRef
  • Is perioperative fasting associated with complications, length of hospital stay and mortality among gastric and colorectal cancer patients? A cohort study
    Isabel Pinto Amorim das Virgens, Ana Lúcia Miranda de Carvalho, Yasmim Guerreiro Nagashima, Flavia Moraes Silva, Ana Paula Trussardi Fayh
    Sao Paulo Medical Journal.2020; 138(5): 407.     CrossRef
  • Survey and Analysis of the Application and Implementations of Enhanced Recovery after Surgery (ERAS) Program for Surgical Patients in the Major Hospitals in Korea
    Eun Young Kim, In Kyu Lee
    Surgical Metabolism and Nutrition.2019; 10(2): 32.     CrossRef
  • Jejum pré-operatório abreviado favorece realimentação pós-operatória com menor custo de internação hospitalar em pacientes oncológicos.
    Phillipe Geraldo de Abreu Reis, Camila Polakowski, Marina Lopes, Danilo Saavedra Bussyguin, Raphaella Paula Ferreira, Vinicius Basso Preti, Flávio Daniel Saavedra Tomasich
    Revista do Colégio Brasileiro de Cirurgiões.2019;[Epub]     CrossRef
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  • 13 Crossref