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Volume 14(3); July 2025

Case Report

[English]

Neurocritically ill patients often encounter challenges in maintaining adequate enteral nutrition (EN) owing to metabolic disturbances associated with increased intracranial pressure, trauma, seizures, and targeted temperature management. This case report highlights the critical role of the nutrition support team (NST) in overcoming these barriers and optimizing EN delivery in a patient with traumatic brain injury (TBI). A 59-year-old man was admitted to the neuro-intensive care unit following TBI. EN was initiated early in accordance with clinical guidelines. By the time of transfer to the general ward, 82.4% of the estimated energy requirement and 102.8% of the protein requirement were met. Despite this, the patient experienced 19.4% weight loss, likely due to underestimation of hypermetabolic demands and delays in EN advancement caused by fluctuating clinical conditions. NST adjusted the nutrition strategy by incorporating high-protein formulas, parenteral nutrition supplementation, and gastrointestinal management. This case report demonstrates the importance of individualized, multidisciplinary nutritional interventions in improving clinical outcomes for neurocritically ill patients.

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Original Articles

[English]
Similarity in Diet Quality Between Children or Adolescents With Obesity and Their Mothers
Hangsook Lee, Jieun Kim, Nayoung Kim, Hyung Gyu Park, Yoon Myung Kim, Kyung Hee Park, Hyunjung Lim
Clin Nutr Res 2025;14(3):164-173.   Published online July 25, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.3.164

Obesity is a multifactorial chronic disease influenced by behavioral, environmental, genetic, and psychological factors. One primary determinant of childhood obesity is the presence of dietary factors commonly acquired through the shared home food environment, which parents can greatly influence. Thus, the present study examined the similarity in diet quality between children or adolescents with obesity and their mothers. We analyzed baseline data collected from the Intervention for Children and Adolescent obesity via Activity and Nutrition study. Seventy mother–offspring dyads were identified, which included children and adolescents with obesity aged 8–16 years and their mothers living in Seoul and Gyeonggi Province, South Korea. Food or nutrient intake and diet quality were evaluated from 3-day food records. Childhood obesity was defined as body mass index ≥ 95th percentile based on the 2007 Korean National Growth Charts. No significant difference was observed in the diet quality score between children with obesity and their mothers. However, correlation coefficients between mothers and their children’s total Diet Quality Index-International (DQI-I) score (r = 0.30) and subcategories, such as variety (r = 0.29), adequacy (r = 0.43), moderation (r = 0.45), and overall balance (r = 0.30), were positively correlated (p < 0.05). Linear regression analysis of the influence of maternal diet quality on offspring diet quality revealed that the maternal DQI-I score influenced the offspring’s DQI-I score, consistent with our prediction. Further studies with larger and more representative samples are needed to confirm the applicability of our findings to all children and adolescent populations.

Trial Registration

Clinical Research Information Service Identifier: KCT0002718

Citations

Citations to this article as recorded by  
  • Prevalence of Obesity and Overweight Among Children in Aseer Region, Saudi Arabia
    Youssef A. Alqahtani, Ayed A. Shati, Ashwag A. Asiri, Samy A. Dawood, Yazan A. Almaker, Abdulmajeed F. AlShahrani, Asma A. Nasser, Seham M. Alqahtani
    Journal of Clinical Medicine.2025; 15(1): 76.     CrossRef
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  • 1 Crossref
[English]
Perceptions of Meat Alternatives Among Adolescents in Korea
Bo-Young Lyum, Su-Ryeon Han, Minseo Choi, Mi-Kyeong Choi
Clin Nutr Res 2025;14(3):174-181.   Published online July 25, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.3.174

We investigated adolescents’ perceptions of meat alternatives and examined the relationships among their views on various types of these alternatives. A survey was conducted with 372 middle and high school students, focusing on their perceptions of 3 categories of meat alternatives: plant-based meats, edible insects, and cultured meats. The relationships among these perceptions were subsequently analyzed. Overall, 77.4% of respondents were aware of meat alternatives, and 38.7% reported having consumed them. Perception levels differed by category, with plant-based meats receiving the highest scores, followed by cultured meats and edible insects. Notably, perceptions across the different categories of meat alternatives were significantly correlated. These findings suggest that increasing awareness about meat alternatives—particularly through education—may help promote sustainable and healthy eating behaviors among adolescents.

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[English]

Chronic obstructive pulmonary disease (COPD) is a major respiratory disorder characterized by irreversible airflow limitation. The role of diet in the prevention and management of COPD is receiving increasing attention. This study aimed to examine the association between the composite intake of vegetables, fruits, meat, and fish and pulmonary function as well as COPD prevalence in a representative sample of Korean adults aged ≥ 40 years using data from the 7th Korea National Health and Nutrition Examination Survey. Higher vegetable intake was associated with significantly better pulmonary function parameters, including forced vital capacity (p < 0.001), forced vital capacity percent predicted (p = 0.050), forced expiratory volume (FEV) in 1 second (FEV1; p < 0.001), FEV1 percent predicted (p = 0.038), FEV in 6 seconds (p < 0.001), and peak expiratory flow (p < 0.001). Furthermore, individuals with a high combined intake of vegetables, fruits, meat, and fish demonstrated a 0.261-fold lower COPD prevalence than those without such intake (p = 0.039). The dietary inflammatory index (DII) was significantly lower among participants without COPD than among those with COPD (mean DII = −3.6947, p = 0.002), indicating that a diet rich in anti-inflammatory nutrients can help reduce COPD risk. These findings suggest that vegetable consumption supports improved respiratory function, and a composite dietary pattern incorporating various food groups may help reduce the prevalence of COPD in the adult population.

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[English]
Effects of Replacing Skipped Meals With Oral Nutritional Supplement on Nutritional Status and Physical Function in Older Adults
Jiyeon Lee, Seong Ah Cho, Seoyoon Choi, Eunbi Han, Hyeri Shin, Yoo Kyoung Park
Clin Nutr Res 2025;14(3):191-203.   Published online July 29, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.3.191

This study evaluated the effects of replacing skipped meals with oral nutritional supplements (ONS) on the nutritional status and functional health of older adults. A total of 29 participants aged ≥ 65 years who regularly skipped at least one meal per day were included in this single-arm study. For 8 weeks, participants consumed two packs of ONS daily (150 mL each, providing 400 kcal and 18 g of protein) as a substitute for skipped meals. Nutritional status, nutrient intake, body composition, and physical function were assessed before and after the intervention. The Nutrition Quotient for the Elderly score significantly increased from 58.97 to 63.62 (p = 0.014). Total nutrient intake, including ONS, significantly improved compared with baseline (p < 0.01). Body weight and body mass index increased significantly from 58.87 to 59.47 kg (p = 0.028) and from 23.9 to 24.18 kg/m2 (p = 0.016), respectively. Calf circumference decreased significantly from 34.1 to 33.39 cm (p = 0.010). Physical function, assessed using the Short Physical Performance Battery, showed significant improvement (p = 0.003). In conclusion, replacing skipped meals with ONS may enhance nutritional status and support functional health in older adults.

Trial Registration

Clinical Research Information Service Identifier: KCT0010184

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[English]

Cataracts are a major cause of vision impairment in older adults and pose a growing concern in aging societies. This study examined the association between dietary macronutrient intake and the odds of having cataracts among 1,619 Korean adults aged ≥ 60 years using data from the 2015–2017 Korea National Health and Nutrition Examination Survey. Cataracts were present in 51.8% of participants. Dietary intake was assessed via 24-hour recall and macronutrient intake was categorized by quartiles and energy ratios. After adjusting for covariates, individuals in the highest quartile of carbohydrate-to-energy intake (> 80%) had 41% higher odds of having cataracts (odds ratio [OR], 1.41; 95% confidence interval [CI], 0.99–2.01), with a significant trend (p for trend = 0.022). In contrast, the highest quartile of protein intake (Q3: 12%–15% energy) was associated with significantly lower odds of having cataracts in women (OR, 0.59; 95% CI, 0.40–0.88). Likewise, fat intake exceeding 18% of total energy was associated with reduced odds of having cataracts (OR, 0.69; 95% CI, 0.49–0.97). Saturated and monounsaturated fat intake also showed inverse associations with the odds of having cataracts. These results suggest that excessive carbohydrate intake, particularly when replacing fats and proteins, may increase the odds of having cataracts in older adults, especially among women. Dietary adjustments aimed at reducing the proportion of carbohydrates and increasing high-quality protein and fat intake may help prevent cataracts in aging populations. Further longitudinal studies are needed to clarify causal relationships and to inform nutritional guideline development.

Citations

Citations to this article as recorded by  
  • Development and Comparison of AI Algorithms for a Predictive Model of Cataracts: Analysis of the Korea National Health and Nutrition Examination Survey (2015–2017)
    Jiyoung Choi, Eunju Park
    Clinical Nutrition Research.2025; 14(4): 297.     CrossRef
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Review Articles
[English]
Association Between Protein Intake and Sarcopenia-Related Indicators Among Korean Older Adults: A Scoping Review
Minjee Han, Kyung-sook Woo, Kirang Kim
Clin Nutr Res 2025;14(3):216-229.   Published online July 25, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.3.216

Protein intake has been identified as a key modifiable factor in preventing and managing sarcopenia, a common age-related condition characterized by the loss of muscle mass, strength, and function. This scoping review aimed to summarize the available literature on the association between protein intake and sarcopenia-related outcomes among Korean older adults and identify current research trends and gaps in this field. The review followed the 5-step methodological framework developed by Arksey and O’Malley for scoping reviews and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist to ensure a comprehensive search strategy. Protein intake was assessed using various methods, including grams per day, grams per kilogram of body weight per day, and intake quartiles. Sarcopenia-related outcomes were categorized into 3 domains as follows: muscle mass, strength, and physical performance. Although most intervention studies demonstrated improvements in muscle mass following protein supplementation, findings on muscle strength and physical function were inconsistent. Cross-sectional studies generally reported better sarcopenia-related outcomes with higher protein intake, particularly when the intake was expressed relative to body weight or analyzed according to quartiles. However, heterogeneity in protein intake assessments and variations in sarcopenia definitions could have contributed to the inconsistent findings across studies. This review highlights the need for applying standardized approaches for protein intake measurement and sarcopenia diagnosis. Future studies should consider the quantity, quality, and timing of protein intake while also focusing on the implementation of integrated, multidisciplinary intervention strategies to promote healthy aging among Korean older adults.

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[English]
Effects of Vaccinium meridionale Swartz (agraz) Supplementation on Inflammatory and Oxidative Stress Markers in Patients With Metabolic Syndrome: A Systematic Review of Randomized Controlled Clinical Trials
Zahra Moghaddas Mashhour, Hanieh Barghchi, Alireza Gheflati, Amir Hossein Mansouri, Zahra Dehnavi, Zahra Khorasnchi, Narjes Bahri Binabaj, Mohsen Sahebanmaleki, Jalil Moshari, Elyas Nattagh-Eshtivani
Clin Nutr Res 2025;14(3):230-240.   Published online July 25, 2025
DOI: https://doi.org/10.7762/cnr.2025.14.3.230

Vaccinium meridionale Swartz (commonly known as agraz or Andean blueberry is a wild fruit native to Colombia and rich in anthocyanins. In this systematic review, we evaluated the effects of agraz supplementation on inflammatory and oxidative stress markers in individuals with metabolic syndrome (MetS). A comprehensive literature search was conducted using PubMed, Scopus, ISI Web of Science, and Google Scholar for articles published up to March 2024, without restrictions on language, publication date, or geographical region. Among the 2,616 records identified initially through the database searches, 6 studies were included in this review. The risk of bias in the included studies was assessed using the Cochrane Collaboration’s tool. Six randomized controlled trials (RCTs) involving 252 participants were analyzed. The intervention durations ranged from 21 days to 4 weeks, and the agraz supplementation doses were between 200 and 250 mL per day. Agraz supplementation significantly reduced urinary and serum levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG). However, among 3 studies examining high-sensitivity C-reactive protein (hs-CRP) levels, only 1 reported a statistically significant decrease in its levels. No significant effects were observed for other inflammatory or oxidative stress biomarkers. Agraz supplementation notable reduced urinary and serum 8-OHdG levels, suggesting potential antioxidant effects; however, its effect on hs-CRP levels remains inconclusive. No significant changes were observed in the levels of the other biomarkers. Further RCTs with larger doses and longer durations are necessary to confirm these findings and to clarify the therapeutic potential of agraz in MetS.

Trial Registration

PROSPERO Identifier: CRD42022369292

Citations

Citations to this article as recorded by  
  • Polyphenolic Compounds from Andean Berry (Vaccinium meridionale Swartz) and Derived Functional Benefits: A Systematic and Updated Review
    Ana Rosa Ramos-Polo, Ivan Luzardo-Ocampo, Sandra Navarro-Gallón, Silvia A. Quijano, Sandra Sulay Arango-Varela
    Foods.2025; 14(22): 3861.     CrossRef
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